Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

　

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

　　The yellow warning of lightning issued before is still high.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　Defense guide:

　　1. Citizens should prepare rain gear to ensure safety.

　　2, drivers pay attention to the road water.

　　Level Ⅳ response of flood prevention platform

　　According to the introduction of the Municipal Flood Control Office, the level IV (level IV) response of the city’s flood control stations started simultaneously.

　　Level 4 (IV) emergency response (blue)

Recently, the Hunan Provincial Health and Health Commission and the Hunan Provincial Department of Education issued the Notice on Strengthening the Prevention and Control of Key Infectious Diseases in Schools in Autumn and Winter. Infectious diseases on campus mainly spread through respiratory tract in autumn and winter, and some spread through digestive tract and contact, so it is easy to break out and spread in campus, so we should pay special attention to prevent the spread of infectious diseases.

According to the epidemic situation and incidence characteristics of infectious diseases, the school hospital has sorted out several knowledge of prevention and treatment of common infectious diseases in autumn and winter, please pay attention to it!

I. Influenza

(A) disease science

Influenza is an acute respiratory infection caused by influenza virus, and it is also a highly contagious and fast-spreading disease. Fog droplets ejected mainly by coughing or sneezing of infected people are transmitted to others through the air, and can also be infected by touching objects contaminated by influenza virus. The main clinical manifestations are high fever, headache, limb aches, fatigue and upper respiratory symptoms such as runny nose and cough. The infirm and the elderly are prone to pneumonia and other complications after infection.

The difference between influenza and common cold

(2) Prevention and control suggestions

1. Before the flu season, it is an effective way to prevent the flu by vaccinating high-risk groups and susceptible groups.

2. Reasonable arrangement of work and rest time: have a regular life, ensure adequate sleep, and avoid the decline of resistance caused by overwork, thus increasing the chance of illness.

3. Pay attention to personal hygiene: don’t spit everywhere, and cover your mouth and nose with a handkerchief or paper towel when sneezing or coughing.

Wash your hands frequently, and wash your hands immediately after touching respiratory secretions (such as after sneezing).

4. Open the window and ventilate several times a day to keep the indoor air fresh. During the high incidence of influenza, try not to go to crowded places with dirty air; You’d better wear a mask when you have to.

5. Effective prevention approaches: early detection, early reporting, early isolation and early treatment. Isolating patients is the most effective way to reduce transmission.

Second, cold diarrhea

(A) disease science

Infectious diarrhea refers to diarrhea caused by intestinal infection of pathogens such as bacteria, viruses, parasites or fungi. Its prevalence is wide, the incidence rate is high, it has the characteristics of acute onset, rapid spread and wide coverage, and it is an important disease that harms health. Mostly due to the intake of unclean diet (such as cold dishes, spoiled shrimp, crabs, drinks, etc.) and water, due to bacterial and viral pollution, coupled with some people’s bad hygienic eating habits, the disease enters the mouth. The clinical manifestation is diarrhea, which may be accompanied by abdominal pain, fever, nausea, vomiting and other symptoms. The stool characteristics often vary with different pathogens, and in severe cases, fever, dehydration, electrolyte disorder, abnormal renal function, acidosis, shock and so on may occur. Infectious diarrhea pathogens are excreted with excreta, which pollutes the environment, food and water sources and can cause outbreaks.

(2) Prevention and control suggestions

1. Pay attention to drinking water hygiene, don’t drink raw water, don’t eat cold and spoiled food, especially seafood and aquatic products.

2. Pay attention to food hygiene, don’t overeat, and eat less food that is easy to carry germs and be bitten by flies; Tableware should be disinfected, and raw and cooked tableware should be separated; Try to eat cooked food, and wash and peel raw fruits and vegetables.

3. Pay attention to personal hygiene, wash your hands before and after meals, do not defecate anywhere, do not dump garbage and dirt, and do not pollute water sources.

4. Report the patients with vomiting and diarrhea in time, and see a doctor as soon as possible for timely diagnosis and treatment.

Third, tuberculosis

(A) disease science

Tuberculosis, also known as "consumption", is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis (commonly known as Mycobacterium tuberculosis). The part often invaded by Mycobacterium tuberculosis is the lung, which is called tuberculosis. The clinical manifestations of tuberculosis are various, and the early symptoms are mild and atypical. It is easy to be confused with other respiratory diseases, such as tracheitis and pneumonia, and it is often ignored, which leads to the delay of medical treatment. Cough, expectoration, hemoptysis or bloodshot sputum are the main symptoms of pulmonary tuberculosis. Most patients with pulmonary tuberculosis have hemoptysis with blood in sputum, and a few patients have hemoptysis with big mouth. In addition, chest tightness, chest pain, low fever in the afternoon, night sweats, general weakness, loss of appetite or weight loss are also common symptoms of tuberculosis.

(2) Prevention and control suggestions

1. Take tuberculosis examination as a compulsory item for physical examination of teachers and students.

2. Do not spit everywhere, cover your mouth and nose when coughing or sneezing, and wear a mask to reduce the spread of tuberculosis.

3. After suspicious symptoms of pulmonary tuberculosis appear or are diagnosed as pulmonary tuberculosis, you should take the initiative to report to the school, and don’t hide your illness or attend classes with illness.

4. Develop the habit of frequently opening windows for ventilation; Do a good job in campus environmental sanitation, and eliminate the dead corner of sanitation.

5. Ensure adequate sleep, reasonable diet, strengthen physical exercise and improve the ability to resist diseases.

Fourth, dengue fever

(A) disease science

Dengue fever is an acute mosquito-borne infectious disease caused by the spread of dengue virus through mosquito bites. Dengue fever has the characteristics of typical importation, suddenness, rapid spread, high incidence, general susceptibility of the population and high mortality of a few severe cases. The clinical features are sudden onset, high fever (sometimes up to 39℃), general muscle pain, joint pain, extreme fatigue, and some patients may have rash, bleeding tendency and lymph node enlargement. At present, the epidemic situation of dengue fever in Southeast Asia, South America, Africa and other places is more serious, and cases of dengue fever have appeared in Yunnan, Guangdong, Zhejiang, Hainan and other regions in China. At present, there are no vaccines and specific therapeutic drugs that can prevent the disease. The focus of treatment is to control pain with painkillers, usually acetaminophen (paracetamol).

(2) Prevention and control suggestions

Avoiding being bitten by mosquitoes is the key. Try to choose light-colored long-sleeved trousers and use mosquito repellent or other mosquito repellent drugs when going out.

2. Screen windows and screen doors should be installed in the residence. You can use mosquito-repellent incense, mosquito-repellent aerosol, etc. in the hotel room before going out. Even in high-end hotels, you should pay attention to indoor mosquito killing. Avoid staying in the dark and humid outdoors such as grass, shade and gazebo for a long time.

3. If symptoms appear, see a doctor in time. If you come back from dengue endemic areas (Yunnan, Guangdong, Zhejiang, Fujian and other domestic endemic areas, Southeast Asia, South America, Africa and other overseas endemic areas), please pay attention to your own health observation. If you have a persistent high fever within 2 weeks, accompanied by symptoms such as headache, orbital pain, muscle and joint pain, nausea, vomiting, rash, etc., you should go to a regular hospital as soon as possible, and inform the doctor of his recent residence history and remind him that he may have dengue fever; When staying at home or in hospital, do a good job in mosquito isolation (especially within 5 days after onset), including using mosquito nets, screen doors and screens, wearing long-sleeved underwear, spraying mosquito repellent and other measures to reduce unnecessary outdoor activities and prevent further spread.

V. Covid-19 infection

(A) disease science

At present, XBB series variants of Omicron subtype have become dominant in most provinces in China, and this trend is likely to continue in the future. The National Bureau of Disease Control and Prevention also said that the epidemic situation of COVID-19 in China is generally at a low level and in a wave-like fashion recently, and the epidemic situation has brought less pressure to local medical systems, so there will be no large-scale epidemic in the short term. However, it should be noted that cases of multiple infections with COVID-19 are more common. Through the search, we can find that the number of COVID-19-infected outpatients in hospitals has increased recently, and most patients are infected with Covid-19 or influenza virus.

(2) Prevention and control suggestions

1. Actively vaccinate. Elderly people aged 60 and above, people aged 18-59 with serious basic diseases, people with low immune function, people with high risk of infection, and people who have completed basic immunization or have been infected with Covid-19 should be actively vaccinated to further strengthen their autoimmune ability.

2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

3. Use drugs rationally and see a doctor as needed. After infection, residents should take corresponding treatment measures according to the severity of their own symptoms, implement self-care at home, reduce contact with their roommates, rationally use symptomatic drugs according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

Six, monkeypox

(A) disease science

Monkeypox (Mpox) is a viral zoonotic infectious disease caused by Mpox virus. The main clinical manifestations are fever, rash and lymphadenopathy. Recently, many provinces and cities in China reported cases of monkeypox. Monkeypox cases are mainly men who have sex with men. Recently, there have been some cases of infection among women and medical staff.

(2) Prevention and control suggestions

1. Pay close attention to the epidemic information of monkeypox in the local area or travel destination in time to avoid direct contact with wild animals in high-incidence countries. Avoid catching, slaughtering and eating local animals raw.

2. Good hygiene habits, frequent cleaning and disinfection, and good hand hygiene.

3. If you find sex with a rash (especially in genitals, perianal parts, etc.), avoid close contact with it. Using condoms can’t completely prevent monkeypox virus infection.

4. The interpersonal transmission of monkeypox is mainly among men who have sex with men. It is suggested that men who have sex with men actively understand the knowledge of monkeypox prevention to avoid or reduce high-risk behaviors.

5. If you have symptoms such as fever, rash and lymphadenopathy of unknown reasons, you should take the initiative to seek medical treatment.

Seven, dog injury

(A) disease science

Rabies is a zoonotic acute infectious disease. Once it breaks out, the mortality rate is close to 100%. According to the data released by the World Health Organization (WHO), rabies still kills 59,000 people worldwide every year, and one person dies of rabies every 9 minutes, and 99% of the cases are caused by dog bites. Main symptoms (rabies): fear of water, fear of wind, pharyngeal muscle spasm and progressive paralysis. Raising awareness of rabies prevention, vaccinating dogs and strengthening post-exposure treatment of human rabies in epidemic areas are the most effective rabies prevention measures at present, and it is also the global consensus on rabies prevention.

(2) Prevention and control suggestions

1. Pet dog owners must consciously raise dogs in accordance with the law, vaccinate cats and dogs, and use leashes when going out to avoid dogs hurting people and spreading rabies virus.

2. Rabies can be prevented and cured. If you are scratched or bitten by a dog/cat, even if the wound is small, you should not be careless. You should seek medical advice in time. It is recommended to go to a medical institution with relevant qualifications for treatment, and do a good job in handling rabies after exposure according to the wound condition and personal immunization history.

3. After being scratched or bitten by a dog/cat, the individual should give first aid: if the wound is deep, especially the bleeding wound, you should first press the wound with a clean cloth to stop bleeding, and then rush to the hospital; If the wound surface is shallow or bleeding is not much, you can first clean the wound with flowing water or soapy water for 15 minutes, then use a clean paper towel to absorb the residual liquid at the wound, and then cover the wound with a clean cloth and seek medical attention as soon as possible. In addition to preventing rabies, we should also guard against other wound infections, such as tetanus infection.

4. Old people and children should receive more protection. Because the elderly and children have weak self-protection ability and lack of awareness of risk prevention, the incidence of animal injuries is high.

Original title: "It is related to health, beware of these infectious diseases! 》

Read the original text

A lawyer’s letter is a legal document sent by a lawyer to the relevant parties in written form after accepting the entrustment, which is usually used to convey claims or legal warnings. In the case of overdue online loans, the receipt of a lawyer’s letter indicates that the creditor has taken further legal measures to urge the debtor to fulfill its repayment obligations. This does not mean to start the lawsuit immediately, but to convey the seriousness of the creditors. If the debtor still refuses to deal with it, the creditors may continue to enter the court prosecution stage. The lawyer’s letter plays a role of warning and prompting repayment, and it is a more serious legal reminder for those who fail to repay after the deadline.

Receiving a letter from a lawyer does not mean that you will be prosecuted immediately. The main function of the lawyer’s letter is to urge the debtor to fulfill the repayment obligation and express the creditor’s intention to take further legal action. Usually, the creditor will give a certain buffer period or repayment period, especially when the repayment period is explicitly mentioned in the lawyer’s letter. If the debtor takes the initiative to take action within three days after receiving the lawyer’s letter, such as repaying the arrears, on the whole, it is unlikely to be prosecuted immediately. Therefore, the debtor should take the lawyer’s letter seriously and raise funds to complete the repayment as soon as possible to avoid greater legal consequences.

Overdue online loans usually have a negative impact on personal credit records, and overdue information will be recorded in the credit information system, which will affect the future loan and credit card approval of individuals. Receiving a lawyer’s letter will not directly increase the impact, but long-term default on debts may not lead to more serious consequences, including being enforced after the court’s decision. Failing to deal with overdue questions in time may also be included in the list of people who have lost their trust (commonly known as "blacklist"), which will bring greater trouble to personal credit and daily life. It is best to communicate with relevant institutions quickly after receiving the lawyer’s letter and try to resolve the problem.

Usually, the lawyer’s letter clearly indicates the repayment period, such as repayment within three days. If the debtor pays the arrears within this period of time, most creditors will choose not to start the proceedings because the arrears have been settled. Litigation is not only time-consuming and laborious, but also needs to pay the corresponding legal fees, which is not the optimal solution for creditors. Repayment within the specified time limit as soon as possible is the best way to avoid legal proceedings. If you can’t repay it in one lump sum, you can try to negotiate with the online loan platform or lawyer to seek a plan for installment repayment.

If the debtor really can’t pay off the debt in one lump sum within three days, the best way is to contact the creditor or lawyer actively, explain his financial situation, and put forward a plan of repayment by installments or deferred repayment. Creditors are often more willing to solve problems by negotiation rather than directly start litigation procedures. If it keeps evading or delaying, the creditor may choose to take legal measures, which will increase the economic pressure and legal risk of the debtor. Active communication is an important step to avoid further legal disputes.

If the debtor still fails to repay after receiving the lawyer’s letter, the creditor may bring a lawsuit to the court according to law and recover the arrears through legal channels. After the court makes a judgment, if the debtor fails to perform the judgment, the creditor may apply for enforcement. This may involve the seizure or freezing of the debtor’s property, and even affect personal life. The issuance of a lawyer’s letter is a preliminary step in the legal process, and its purpose is to hope that the debtor can consciously repay the loan and avoid the extra time and cost brought by the litigation stage. The stage of dealing with the letter from the lawyer is the ideal time.

After receiving the lawyer’s letter, the debtor should carefully read the contents of the letter and check the amount owed by the online loan, the number of days overdue and the relevant clauses in the lawyer’s letter. If the amount is found to be inconsistent or the terms are questioned, you should contact the lawyer or creditor in time, raise objections and keep relevant evidence. If the debtor has encountered irregularities or usury in the process of online lending, he can also report to the relevant regulatory authorities and safeguard his rights and interests by legal means. When dealing with lawyers’ letters, we should keep calm, not only avoid expanding questions, but also strive to protect our legitimate rights and interests.

Long-term failure to deal with overdue online loans may lead to a series of serious consequences, including damage to credit records, legal proceedings, property enforcement and being included in the list of untrustworthy people. The list of untrustworthy people will have a significant impact on personal life and work, such as being unable to handle high-consumption behaviors, restricting high-speed rail and air travel. Legal proceedings may also generate additional penalty interest and lawyer fees, increasing the debt burden. It is urgent to deal with overdue debts, and solving problems as soon as possible can reduce the impact on personal life and economic status.

According to CCTV news, according to a report by the Japan Broadcasting Association on March 27th, local time, the Japanese Ministry of Health, Labor and Welfare announced the second death case suspected of taking a health product containing monascus from Kobayashi Pharmaceutical Company on March 26th, and the number of people admitted to the hospital has increased to 106.

Earlier, the Japanese Ministry of Health, Labor and Welfare had investigated Kobayashi Pharmaceutical Company and found that there was a new death report in addition to a previously announced death case.

Based on the Food Hygiene Law, Japan’s Ministry of Health, Labor and Welfare has asked Osaka headquarters where Kobayashi Pharmaceutical Company is located to take measures including product abandonment.

In view of the fact that many people were hospitalized and two people died after taking products containing monascus from Kobayashi Pharmaceutical Company, the Japanese Ministry of Health, Labor and Welfare will hold a meeting with the Consumer Department, the Ministry of Agriculture, Forestry and Fisheries and other relevant departments on the 27th to discuss future countermeasures.

According to Japanese media reports on the 27th, the Osaka municipal government of Japan ordered Kobayashi Pharmaceutical Company to recall three products, including "red yeast cholesterol granules".

Consumers die after taking health care products.

Kobayashi Pharmaceutical Emergency Recall

Previously, Kobayashi Pharmaceutical Co., Ltd. said that a consumer who took the company’s health care products containing monascus ingredients died of kidney disease. Some consumers suffer from diseases in kidney and other parts after using this health care product, and they are hospitalized, and some even need dialysis.

On March 26, Kobayashi Pharmaceutical updated the notice asking consumers to stop using the company’s products containing monascus ingredients and to recall them independently. According to the notice, the consumer took the company’s health care product containing monascus ingredients-monascus cholesterol granules. However, the notice did not disclose the relevant information of the consumer and the time of death.

The notice said that it has been confirmed that the consumer continued to buy red yeast cholesterol granules from April 2021 to February 2024. The company is investigating whether there is a causal relationship between the consumer’s death and taking the above health care products.

According to Kyodo News, since February 2021, monascus cholesterol granules have been sold in e-commerce channels and stores, and about 1.06 million bags have been sold by the end of February this year.

Three products involved
Are health care products for improving cholesterol.

The following is a list of three recalled products released by Kobayashi Pharmaceutical Company official website, all of which are health products for improving cholesterol. Please be careful not to buy or continue taking it.

China e-commerce platform removes products involved.

Consumers can return goods and get a refund.

Kobayashi Pharmaceutical Co., Ltd. is an old Japanese pharmaceutical company with a history of more than 100 years, and many of its products are quite popular. According to the company, monascus is a raw material produced by mixing monascus with steamed rice for fermentation. The company publicizes that this ingredient is expected to reduce the cholesterol value of low density lipoprotein.

The reporter searched a number of domestic e-commerce platforms and found that there are currently no three related products sold on the official e-commerce platform of Xiaolin Pharmaceutical, but there are still purchasing merchants selling related recalled products.

Kobayashi Pharmaceutical China Company said, "The company has received reports that it may cause kidney diseases and other problems after eating, and some of its products are sold to China through cross-border channels. If a consumer has eaten it and feels unwell, contact customer service, and the products that have not been eaten will be returned and refunded. "

On March 22nd, @ Kobayashi Pharmaceuticals issued a notice to remind consumers who have red herring cholesterol granules (60, barcode 4987072059708) to stop eating.

Up to now, the products involved have been removed from the official store of Kobayashi Pharmaceutical, the e-commerce platform mentioned in the notice. According to the reporter’s inquiry, multiple e-commerce platforms have been unable to search for this product.

Kobayashi pharmaceutical president bowed and apologized.

Admit that decision-making is slow

On the evening of March 22nd, President Kobayashi held a press conference and bowed to apologize for this issue.

According to Japanese media reports, the analysis results on the 16th of this month showed that some raw materials of monascus may contain unknown ingredients, but the company did not announce the recall until the 22nd. In this regard, the president of Kobayashi Pharmaceutical admitted that the decision was slow.

Another five Japanese companies issued a recall announcement.

Among the 18.5 tons of monascus raw materials produced by Kobayashi Pharmaceutical in 2023, about 16 tons of raw materials were sold to other companies for brewing and food manufacturing, except for their own health care products. At present, Kobayashi Pharmaceutical has issued a recall request to all 52 enterprises that purchased its monascus raw materials through its sales company. Affected by this, some food, brewing and other enterprises that use Xiaolin Pharmaceutical’s red yeast raw materials have also announced the recall of related products.

It is understood that the company is working hard to confirm the sales partners and recalls, and it is expected that the recall scale will be further expanded.

The reporter’s investigation found that at present, five Japanese companies have issued relevant recall announcements and announced related products. The names of the five enterprises are respectively Baojiuzao Co., Ltd., ZERO PLUS Co., Ltd., Doufu Co., Ltd. Nagoya Store, Takeya Co., Ltd. and Jiwen Food Co., Ltd.

Baojiuzao Co., Ltd.

On March 24th, Japan Baojiu Brewery Co., Ltd. announced that it had decided to recycle about 96,000 bottles of this product by itself because a wine produced by this company used red yeast raw materials provided by Kobayashi Pharmaceutical Company. At present, there are no reports of health damage related to this product of Baojiu Brewery Company.

According to the wine manufacturer, this wine has only been exported to Singapore and Taiwan, China, and has not entered the Chinese mainland market.

ZERO PLUS co., ltd

Japan’s ZERO PLUS Company issued a recall notice on March 22nd, saying that there may be unknown ingredients in the raw materials of red yeast in the thick cheese biscuits sold by its KUMITE brand. At present, the specific information of this ingredient cannot be determined. In order to prevent the safety problem from further expanding, it will be recycled independently from now on.

Doufu corporation company Nagoya branch

The recall announcement issued by the Nagoya Pastry Store of Doufu Co., Ltd. said that because its eight products contain red rice malt ingredients produced by Kobayashi Pharmaceutical, there are potential health risks, so they will take the initiative to recall these products and suspend sales.

Takeya corporation

On March 25th, Takeya, a Japanese miso production company, issued a notice that the product "Low-salt Monascus Miso" used the raw materials of Monascus produced by Kobayashi Pharmaceutical, and the sales of this product will be stopped from now on and recycled independently.

Jiwen food co., ltd

Japan’s Jiwen Food Company issued a notice on March 24th, stating that the products "domestic squid pickled products" and "squid pickled products" used the raw materials of red koji produced by Kobayashi Pharmaceutical, so they were recycled independently from now on. If the products are sent to the address designated by the company, the company will refund the payment in the future.

Xiaolin Pharmaceutical’s market value evaporated by over 4.2 billion yuan.

It is reported that Kobayashi Pharmaceutical (China) Co., Ltd. is a wholly-owned subsidiary of Kobayashi Pharmaceutical Co., Ltd.

According to the national enterprise credit information publicity system, Kobayashi Pharmaceutical (China) Co., Ltd. was established in Shanghai on April 9, 2018 with a registered capital of US$ 77,982,400. The legal representative is Matsushita Tuoye, and the company is 100% owned by Kobayashi Pharmaceutical Co., Ltd.

As of the morning of 27th, the share price of Kobayashi Pharmaceutical Co., Ltd. fell by 3.53%, with a total market value of 381.7 billion yen. Since the fermentation of the event, Kobayashi Pharmaceutical has fallen by nearly 20%, and its total market value has evaporated by more than 90 billion yen (about RMB 4.29 billion) compared with the closing on March 22.

Netizen: I didn’t expect health care products to be fatal.

In response to this matter, some netizens said that it was "terrible", "too scary" and "I didn’t expect health care products to be deadly", and some netizens were worried about whether other products such as warm babies and antipyretic stickers of this brand could still be used.

(Yangcheng Evening News Yangcheng School Comprehensive CCTV News, Beijing Daily, Xinhua News Agency, China News Network, Zhongxin Jingwei, Overseas Network, Beijing Youth Daily, User Comments)

Original title: Health care products are still dying? 2 deaths and 106 people have been hospitalized! Kobayashi Pharmaceutical urgently recalled, and these products should also be noted →　

CCTV News:In Chongqing, with the optimization and adjustment of epidemic prevention and control policies, the number of emergency department patients in the First Affiliated Hospital of Chongqing Medical University surged, especially the number of emergency medical patients increased by 4-5 times, most of whom were infected by Covid-19. In the past two days, the reporter from the reception desk came to the emergency department of the hospital and recorded the work of medical staff.

As soon as the reporter arrived at the hospital, a 120 ambulance was ready to leave. The doctor Deng Ying told us that they were going to the nursing home to pick up a critically ill patient. When they came to the nursing home, Deng Ying and the nurse learned that the old man had not eaten for several days and had symptoms such as difficulty breathing.

After carrying the old man to the ambulance, the nurse on board quickly inserted oxygen into the old man and connected the monitoring equipment. Ten minutes later, the ambulance rushed back to the hospital from the nursing home, but there was no bed in the emergency room. What was even more worrying was that the family members could not be contacted.

Although the family members could not be contacted, the first aid could not wait. Several medical staff quickly added a bed for the elderly and made various emergency treatments.

With the cooperation of several medical staff, Deng Ying finished the examination for the elderly. According to the examination results, they gave the elderly corresponding treatment and plan. Soon, the problems such as poor breathing of the elderly were alleviated. Deng Ying said that recently, due to the shortage of emergency personnel, she was transferred from obstetrics and gynecology to support. At present, there are 22 doctors in the emergency department, many of whom are transferred from other departments like Deng Ying. Most of them have been infected with Covid-19. Faced with the emergency volume of more than 400 people at the peak, they are a little tired, but they still try their best to treat every patient.

At the moment, the medical staff in the emergency department are rescuing a 19-year-old boy. Because of renal insufficiency and other diseases, the boy developed respiratory failure after being infected with Covid-19, and he is in urgent need of ventilator support.

After the coordination of the dean, a bed was finally found in the respiratory intensive care unit, but the department’s non-invasive ventilator had been used up and had to be transferred from the geriatrics department. The patient was successfully transferred to the respiratory intensive care unit. Five hours later, the reporter came to the intensive care unit again and found that all the indicators of the patient’s body tended to be stable.

According to the hospital, at present, the beds in various departments, especially the emergency department, have been overloaded. How to ensure that patients can be treated in time and that critically ill patients can live in the intensive care unit in the later stage?

Zhou Fachun, Director of Department of Critical Care Medicine, First Affiliated Hospital of Chongqing Medical University:Patients with relatively stable condition can be transferred to other specialized wards at the first time, so as to ensure that the utilization rate of ICU beds can really serve the critical patients in need.

For non-critical patients, neurology, cardiovascular medicine and other departments have also vacated many beds.

In the emergency department, doctors and nurses are still busy, and 2023 has quietly arrived.

　　Twelve years old is a happy age. You can go to school with a small bag on your back every day, cuddle up in your mother’s arms and eat delicious meals cooked by your mother &hellip; &hellip; But for 12-year-old Xiaomei (a pseudonym), all this seems to have become a long memory. After my mother went to Nanjing for business last year, she could only live in a cramped storage room of about 10 square meters in a residential area in Economic Development Zone of Suqian City, washing and cooking for her 16-year-old brother and 9-year-old sister, day after day. For her, the future is looking forward to growing up earlier. "Mom said that when she is 16 years old, she can go out and find something to do."

　　Yangzi Evening News reporter Gao Fengwen/photo

　　The girl cooks three meals a day according to the "recipe" on the wall

　　On the afternoon of January 19th, the reporter of Yangzi Evening News came to Xiaomei’s house according to the address provided by enthusiastic citizens. This is a storage room on the first floor of the community, only about 10 square meters. When you walk into the room, a musty smell comes.

　　Two 1.5-meter-wide beds are placed almost next to each other, occupying most of the room. Walking in from one end of the bed, the right hand side was separated from a bathroom with a washing machine outside. The prominent place in the corner of the room, with an area of about 1 square meter, became a kitchen. On the small round table, there was a single-headed gas stove with a range hood on it, and pots and various items were randomly placed next to it. The iron pot was open, and there was a bowl of hot sauce on the empty and dirty chopping board.

　　There is an air conditioner hanging on the wall opposite the bed. Under the air conditioner, there is a piece of stained paper, the edge of which has been curled. On the paper, there are three meals a day arranged by the mother for the children:

　　Breakfast 7&mdash; 9 (Reporter’s Note: Meal time) (only one can be selected): milk +2 eggs, millet porridge +2 eggs, millet porridge +4 steamed buns (pure meat);

　　Chinese food 11&mdash; 13, pancakes+scrambled eggs with tomatoes, steamed bread+fried meat with onions, pancakes+fried mung bean sprouts with leeks, fried shredded pork with celery+pancakes, and 4 steamed buns;

　　Dinner 5&mdash; 7. One cucumber, one apple, one tomato and half pitaya.

　　Xiaomei said that at first, it was my brother who cooked the meal. Later, my brother went out to find something to do, and he began to cook for his brother and sister according to the "recipe" for three meals a day prescribed by his mother. Every time my mother leaves, she will specially cook a bowl of hot sauce for the three brothers and sisters, which has become the next meal for the three brothers and sisters for a month.

　　On the morning of 20th, the reporter of Yangzi Evening News came to the community where the children lived again, only to see the door locked and the sisters playing with the children in the community.

　　"My sister’s cooking is delicious. Let’s have dinner at my house at noon." Near noon, my sister sent an invitation to a six or seven-year-old girl. Then, the three men walked into the house and the door closed.

　　Parents divorced and all three children dropped out of school.

　　In an interview with reporters, Ms. Li, the mother of three children, happened to have a rest and rushed back to Suqian to take care of her children. "I usually take four days off a month and come back once to see them. This time I only come back once every two months."

　　Ms. Li said that she is an Anhui native. After she married Fengxian County, Xuzhou, she gave birth to three children. The older one is a boy, now 16 years old, and the two younger ones are girls. Xiaomei is now 12 years old and the youngest child is only 9 years old. Ms. Li said that due to family breakdown, among the three children, the older child dropped out of school in the first grade, Xiaomei dropped out of school in the sixth grade, and the youngest daughter was forced to drop out of school just after entering the first grade.

　　Last May, she came to Suqian with three children and started her life again. Ms. Li rented a storage room in the community at the monthly price of 450 yuan, and the family settled down temporarily. Soon, Ms. Li found a job selling cosmetics, going out early and returning late every day, earning more than 2,000 yuan a month. Last October, Ms. Li went to Nanjing to do cosmetics business and earned more than 3,000 yuan a month. Every month, she will transfer more than 1,000 yuan to her son through WeChat transfer, which is the monthly living expenses of the three brothers and sisters.

　　For Ms. Li, although people have arrived in Nanjing, her heart is still concerned about Suqian’s three children. "I call several times a day, send WeChat, tell her how to cook, and ask if the clothes are hanging &hellip; &hellip;”

　　After learning about this special family, the residential property was very sympathetic and began to do some odd jobs with the brother of three children. "On the one hand, it can take care of him, guide him, prevent him from being adversely affected, and go to the wrong road. At the same time, it can also make him supplement some household expenses."

　　So, after her brother went out every day, 12-year-old Xiaomei took over the burden of cooking.

　　The police are worried about safety.

　　On the afternoon of 19th, when interviewed by Yangzi Evening News reporter, the police in the jurisdiction happened to visit Xiaomei’s home. "At the end of last year, we found this special family in the community investigation visit." The police said that at first, the family was very resistant to outsiders and could not communicate. After many times of communication, they learned something. "I am very worried about their safety. I can only come and walk more, and the community security guards will take care of them."

　　conversation

　　"I want to go to school but I don’t want to go to school"

　　Reporter: Do you cook?

　　Xiaomei: Do it. My brother’s cooking is not delicious.

　　Reporter: So you can cook?

　　Xiaomei: My mother always calls me to tell me what to do before cooking.

　　Reporter: Do you sleep after dinner at night?

　　Xiaomei: When my brother comes back at night, let us sleep after dinner. But I can’t sleep. My sister always cries for hours, which wakes me up and won’t fall asleep until 12 o’clock.

　　Reporter: Usually all the children in the community go to school. What do you do?

　　Xiaomei: Go home to sleep, and then get up to buy food and cook.

　　Reporter: Do you want to go to school?

　　Xiaomei: Yes and no. I want to go to school because I am bored at home, and I don’t know a word out of ten when I read a book, and no one teaches me. I don’t want to go to school, because I have to board and live at school, and my sister goes to school, so there is no one to pick me up.

　　Reporter: Do you want your mother to accompany you?

　　Xiaomei: Yes! But it’s no use, because my mother is going out. How can we live without going out?

The new semester has arrived, and friends should start studying hard! In English learning, many grammatical problems will become a problem. Xiaobian will publish some articles about English spelling, punctuation, grammar, vocabulary description and writing tips one after another this semester, hoping to help English learning.

There are several differences in spelling between British English and American English. These differences are often due to the fact that British English often retains the spelling of the source language, such as French, while American English adjusts the spelling in order to correctly reflect the actual pronunciation of words.

If you want to write something for the British, you should only use British spelling. In a few cases, American spelling is also acceptable in British English, especially words ending in -ize/-ization. In this case, -ise/-isation or -ize/ization can be used in British English, but it is important to be consistent in an article and use one spelling from beginning to end.

Today, we list several major spelling differences and compare the spelling differences between British and American English.

1) Words ending in–re: English ends in–re; American style ends with -er.

2) Words ending in -our: English ends in -our; American usually ends with -or.

3) Words ending in -ize or -ise: In British English, verbs spelled with -ize or -ise are acceptable; In American English, it is always spelled -ize.

4) Words ending in -yse: In British English, this kind of verb is written as-yse; American English is always writing -yze.

5) Words ending in vowel+letter L: In British spelling, when a verb ends in vowel+letter L, if you need to add vowel, you will double write L; In American spelling, there is no need for double writing.

6) diphthongs’s spelling: In British English, diphthongs ae or oe are both two letters; In American English, they are all written as a letter e.

Tip: In American English, some specific words, such as archaeology, still retain the spelling of ae. This is the standard spelling method, and if it is only written as e, it is archeology, which is usually acceptable.

7) Nouns ending in -ence: nouns ending in -ence in British English are written as -ense in American English.

8) Nouns ending in–OGUE: English spelling is–OGUE; American spelling can be -og or -ogue.

This difference is not difficult to grasp. In American English, the writing of analogue is acceptable, but not universal; The spelling of catalog has become the standard form in the United States, and the writing of catalog is not uncommon; Dialogue is still more popular than dialogue.

Welcome to pay attention to WeChat WeChat official account: OxfordDictionaries and Weibo: @ Oxford Dictionaries Weibo.

(Source: Oxford Dictionary Editor: Julie)

Jiaojiang release

Recently, Zhejiang Provincial Department of Human Resources and Social Security, Zhejiang Federation of Trade Unions and Zhejiang Provincial Committee of the Communist Youth League jointly issued a document to publish the "List of Personnel of Zhejiang Artisans Training Project in 2023", and 8 people from Jiaojiang District were selected.

Come and see, are there any craftsmen you know?

Wang Yongjun

Wang Yongjun, male, born in June, 1977 in Taizhou, Zhejiang Province, now works in Zhejiang Haizheng Pharmaceutical Co., Ltd., as deputy director of the workshop, chief chemical engineer and engineer, mainly responsible for the production of anti-tumor APIs. Won the honors of Zhejiang craftsman, Zhejiang Golden Blue Collar, the second prize of Zhejiang Workers’ Vocational Skills Competition, the second prize of group, Taizhou craftsman, five-star Taizhou mechanic, Taizhou technical expert, Jiaojiang technical expert, Jiaojiang Wang Yongjun technician studio leader, Jiaojiang model worker craftsman innovation studio leader, etc. Instructed and trained a number of technicians and senior engineers, and achieved excellent results in the vocational skills competitions of chemical general control workers in Zhejiang, Taizhou and Jiaojiang. One person won the Zhejiang Excellence Award, three people won the Taizhou Technical Expert, two people won the Taizhou May 1st Labor Medal and two people won the Jiaojiang Technical Expert.

Zhao erqiang

Zhao Erqiang, male, born in November 1988 in Tianshui, Gansu Province, party member, graduated from College of Medicine and Chemical Engineering of Taizhou University, and is a chemical inspector technician and engineer. Now he works in Zhejiang Haizheng Pharmaceutical Co., Ltd. as QC supervisor, mainly responsible for the process verification and commercial testing of preparation products. He was honored as a representative of the 15th Communist Youth League Congress in Zhejiang Province, a Zhejiang craftsman, a Zhejiang young craftsman, a Taizhou May 1st Labor Medal, a Taizhou skill master, a Taizhou craftsman, a five-star Taizhou mechanic, a practical talent shortage for enterprises in Jiaojiang District, and a Jiaojiang craftsman. Over the past three years, five technicians and ten senior technicians have been trained, many of whom have achieved excellent results in the vocational skills competition of chemical inspectors in Taizhou and Jiaojiang District, one has won the Zhejiang Young Craftsman, two have won the May 1st Labor Medal in Taizhou, and three have won the Taizhou Technical Expert.

Wang zhi

Wang Zhi, male, born in May, 1983 in Taizhou, Zhejiang Province, party member, graduated from Chongqing University. He is a senior engineer, locksmith technician and professional qualification appraiser of the Ministry of Human Resources and Social Security. Now he works for Jack Technology Co., Ltd. as the director of seam development. He was awarded the honors of Zhejiang craftsman, Taizhou craftsman, young scientific and technological talents in sewing machinery industry, Taizhou 211 talents, advanced individual in United front work in Jiaojiang District, young post expert in Jiaojiang District, leader of model worker innovation studio for high-skilled talents in Jiaojiang District, outstanding skilled talents in Jiaojiang District, and practical talents in enterprises in Jiaojiang District. Engaged in sewing machine development and technological innovation for 18 years, presided over and participated in the development of more than 30 new products and more than 50 new technologies. Drafted one group standard of Zhejiang Manufacturing and one group standard of "Made in Zhejiang", published two papers, obtained more than 40 authorized invention patents and more than 50 utility model patents, and trained more than 10 technical business backbones for the company, including 3 technicians and 3 senior engineers.

Wang Hui

Wang Hui, male, born in September, 1983 in Taizhou, Zhejiang Province, party member, graduated from Dalian University of Technology as a fitter technician and mechanical engineer, and now works for Jack Technology Co., Ltd. as the quality director of metalworking workshop, mainly responsible for the design and debugging of process/fixture, workshop project transformation and workshop quality management. Zhejiang craftsman, Taizhou craftsman, Taizhou technical expert, Taizhou youth post expert, four-star Taizhou mechanic and other honors. Participated in the research and development of more than 20 new products, process and tooling design, and five rationalization suggestions for safety production won the honor of "Top Ten Golden Ideas" and "Silver Ideas" in the city; Published 2 papers and won 1 utility model patent; Technical innovation, 9 production line projects have a total of more than 100 innovations, saving nearly 6.5 million yuan/year; A number of studies won the first and second place in QCC improvement achievements of enterprises.

Mingming Fan

Mingming Fan, male, born in July, 1987 in Quzhou, Zhejiang Province, party member, senior technician of CNC lathe, leader of the workshop of famous CNC lathe machining technicians in Mingming Fan, Taizhou, and leader of the workshop of Mingming Fan skill masters in Jiaojiang District, now works in Taizhou Technical School as a mechanical professional teacher and senior practice instructor. He was awarded the honors of Zhejiang Technical Expert, Taizhou Chief Technician, Taizhou Excellent Instructor of CNC Car, Taizhou Excellent Instructor of Comprehensive Processing, Jiaojiang Excellent Skilled Talents, Jiaojiang Top Ten Skilled Experts, Jiaojiang Youth Post Expert and Jiaojiang Outstanding Youth Pioneer. He won the first prize 3 times and the second prize 2 times in Zhejiang CNC Competition. Publish 3 textbooks, one as the chief editor and one as the deputy chief editor; Published 5 professional and technical papers; Presided over 4 provincial and municipal projects and participated in 6 provincial and municipal projects; The students have won many awards in national, provincial and municipal numerical control skill competitions.

Zheng jiazheng

Zheng Jiazheng, male, born in September 1999 in Taizhou, Zhejiang Province, graduated from Hangzhou Wanxiang Vocational and Technical College as a CNC lathe technician, and now works for Zhejiang Chengxin Medical Equipment Co., Ltd. as a CNC machining technician, mainly responsible for CNC lathe processing programming and process improvement. Won the honor of Zhejiang craftsman, Zhejiang young craftsman, Taizhou craftsman, Taizhou technical expert, Jiaojiang craftsman, Jiaojiang technical expert and so on. Participated in the national 3D digital innovative design competition and won the first prize and the third prize respectively in Zhejiang Selection Competition, the first prize in Taizhou Vocational Skills Competition and the third prize in Taizhou Youth Vocational Skills Competition. Participated in more than ten technical transformation projects of the company, and solved technical problems for the company.

Chen zhong

Chen Zhong, male, born in February, 1977 in Baishan, Jilin Province, graduated from Dalian University of Technology, and is a senior technician and engineer of equipment inspection. Now he works for Zhejiang Haixiang Pharmaceutical Co., Ltd. as the technical director of engineering equipment, responsible for the daily operation and maintenance, technical upgrading and technological innovation of enterprise equipment production lines. He was honored as a Zhejiang craftsman, a "100 million" high-skilled leading talent in Zhejiang Province, an "outstanding high-skilled leading talent" in Quzhou City, Zhejiang Province, a "scientific expert" in Zhejiang Science and Technology Department, a Taizhou craftsman, a five-star Taizhou mechanic and a Jiaojiang craftsman. Declared 8 invention patents, 7 utility model patents and 4 chief editor’s papers. Trained 2 senior technicians, 4 technicians, 1 young craftsman from Zhejiang and 2 four-star Taizhou technicians. His apprentice won the first place in Taizhou Electrician Competition, the May 1st Labor Medal from Taizhou, the Golden Blue Collar from Jiaojiang and the second place in Jiaojiang District Electrician Competition.

Nie Yujian

Nie Yujian, male, born in Taizhou, Zhejiang Province in February 1999, graduated from zhejiang mechanical and electrical Vocational and Technical College, and is an ordinary lathe/CNC lathe technician. Now he works in Zhejiang Tongyu Variable Speed Machinery Co., Ltd. as a lathe/milling worker of fixture group, mainly responsible for the trial production and processing of fixture. He was awarded the second prize of Zhejiang Craftsman, Zhejiang Young Craftsman, Zhejiang Workers’ Lathe Vocational Skills Competition, the first prize of Taizhou Second Vocational Skills Grand Racer, Taizhou Skills Master, Taizhou May 1st Labor Medal, Jiaojiang District Technical Expert and other honors. Participate in the company’s multi-station four-sided milling technology of reducer box, grinding technology of reducer transmission shaft, trial-manufacture and processing of various fixtures such as various boring and milling rods and assembly tools.

Source: Jiaojiang Labor and Personnel

Editor: Ye Yuxin

Editor: Zhang Qi

Original title: "Provincial List, 8 people in Jiaojiang"

Read the original text

　　General Secretary of the Supreme Leader pointed out at the National Ecological Environmental Protection Conference that the construction guarantee system of beautiful China should be improved. Co-ordinate resources in various fields, gather all forces, and lay a good combination of the rule of law, market, science and technology and policy. Since the 18th National Congress of the Communist Party of China, the "four beams and eight pillars" of China’s system of ecological civilization system have been gradually constructed, which has escorted green mountains and green rivers and provided a solid guarantee for the modernization of harmonious coexistence between man and nature. today，Dangjian. comI have sorted out some relevant important expositions of the Supreme Leader General Secretary, and studied and understood them with you.

　　It is necessary to strengthen the guarantee of the rule of law

　　To promote green development and build an ecological civilization, we should focus on establishing rules and regulations, protect the ecological environment with the strictest system and the strictest rule of law, improve the management system of natural resources assets, strengthen the supervision of natural resources and ecological environment, promote environmental protection inspectors, implement the compensation system for ecological environmental damage, and improve the system of public participation in environmental protection.

　　&mdash; &mdash; On May 26, 2017, the Supreme Leader’s speech at the 41st collective study in the 18th the Political Bureau of the Central Committee.

　　It is necessary to strengthen the protection of the rule of law, promote the revision of relevant laws in the fields of ecological environment, resources and energy as a whole, implement the strictest ecological environment management system of above-ground and underground, land and sea as a whole, and regional linkage, fully implement the pollutant discharge permit system, improve the natural resource asset management system, and improve the land and space use control system.

　　&mdash; &mdash; In July, 2023, the Supreme Leader’s Speech at the National Ecological Environment Protection Conference.

　　We should improve the economic policy of green and low-carbon development.

　　Improve the green and low-carbon policy system. It is necessary to further improve the "double control" system of energy consumption, and the newly added renewable energy and raw material energy are not included in the total energy consumption control. It is necessary to improve the "double carbon" standard, build a unified and standardized carbon emission statistical accounting system, and promote the transformation from "double control" of energy to "double control" of total carbon emission and intensity.

　　&mdash; &mdash; On January 24, 2022, the Supreme Leader’s speech at the 36th collective study in the 19th the Political Bureau of the Central Committee.

　　It is necessary to improve the green and low-carbon economic development policy and strengthen financial support, tax policy support, financial support and price policy support.

　　&mdash; &mdash; In July, 2023, the Supreme Leader’s Speech at the National Ecological Environment Protection Conference.

　　It is necessary to promote a better combination of effective markets and promising governments.

　　It is necessary to actively explore the path to promote the transformation of green mountains and green hills into Jinshan Yinshan, select qualified areas to carry out pilot projects of eco-product value realization mechanism, and explore the path of sustainable eco-product value realization led by the government, with the participation of enterprises and all sectors of society.

　　&mdash; &mdash; On April 26, 2018, the Supreme Leader’s speech at the symposium on further promoting the development of the Yangtze River Economic Belt.

　　It is necessary to promote a better combination of an effective market and a promising government, integrate resources and environmental factors such as carbon emission rights, energy use rights, water use rights and emission rights into the overall plate of factor market allocation reform, support market transactions such as transfer, transfer, mortgage and shareholding, accelerate the construction of an environmental credit supervision system, standardize the environmental governance market, and promote the healthy development of environmental protection industries and environmental services.

　　&mdash; &mdash; In July, 2023, the Supreme Leader’s Speech at the National Ecological Environment Protection Conference.

　　It is necessary to strengthen scientific and technological support

　　Accelerate the green and low-carbon scientific and technological revolution. We should pay close attention to tackling key problems of green and low-carbon technologies and accelerate the research and development, popularization and application of advanced and applicable technologies. It is necessary to establish and improve the evaluation and trading system of green and low-carbon technologies and accelerate the transformation of innovation achievements. It is necessary to innovate the talent training mode and encourage colleges and universities to speed up the construction of related disciplines.

　　&mdash; &mdash; On January 24, 2022, the Supreme Leader’s speech at the 36th collective study in the 19th the Political Bureau of the Central Committee.

　　It is necessary to strengthen scientific and technological support, promote the self-reliance of green and low-carbon science and technology, take tackling climate change and controlling new pollutants as key areas of national basic research and scientific and technological innovation, pay close attention to tackling key core technologies, implement major actions of scientific and technological innovation in ecological environment, cultivate a high-level team of scientific and technological personnel in ecological environment, deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China and build a green and intelligent digital ecological civilization.

　　&mdash; &mdash; In July, 2023, the Supreme Leader’s Speech at the National Ecological Environment Protection Conference.